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Evaluation of cognitive learning, memory, psychomotor, immunologic, and retinal functions in healthy puppies fed foods fortified with docosahexaenoic acid-rich fish oil from 8 to 52 weeks of age.

Dietary fortification with fish oils rich in DHA and possibly other nutrients implicated in neurocognitive development following weaning improved cognitive, memory, psychomotor, immunologic, and retinal functions in growing dogs.

Omega-3 Plus

Journal of the American Veterinary Medical Association , Vol.241(5), p.583-594

Multicenter Veterinary Practice Assessment of the Effects of Omega-3 Fatty Acids on Osteoarthritis in Dogs

Ingestion of the test food raised blood concentrations of omega-3 fatty acids and appeared to improve the arthritic condition in pet dogs with osteoarthritis.

JAVMA; 2010; Vol 236, No. 1.

The role of dietary omega-3 and omega-6 essential fatty acids in the nutrition of dogs and cats: a review

The use of fatty acid supplements has proved to be beneficial in the treatment of several pathogenic  conditions, such as chronic inflammatory diseases, atopy, chronic renal insufficiency, and some types of cancer. Therefore, particular attention should be paid to the type and quantity of fat sources that are used when diets for dogs and cats are formulated, in order to assure the optimal amount and balance of omega-3 and omega-6 fatty acids in the food.

Progress in Nutrition; 2004; VOL. 6, N. 2, 000-000.

Association of Body Weight and Body Condition with Survival in Dogs with Heart Failure

These results suggest that changes in body weight might be an important consideration in the survival of dogs with heart failure

Journal of Veterinary Internal Medicine; 2008; Vol. 22, Iss. 3, pp 561-563

Nutritional Alterations and the Effect of Fish Oil Supplementation in Dogs with Heart Failure

The purposes of this study were to characterize nutritional and cytokine alterations in dogs with heart failure and to test the ability of fish oil to reduce cytokines and improve clinical outcome.

J Vet Intern Med Nov-Dec 1998;12(6):440-8.

Omega‐3 Fatty Acids in Boxer Dogs with Arrhythmogenic Right Ventricular Cardiomyopathy

These data suggest that fish oil, but not flax oil, supplementation for 6 weeks reduces arrhythmia in Boxers with ARVC and that it could be useful in treating this common disease. Further studies are needed to determine optimal dose and duration of treatment.

Journal of Veterinary Internal Medicine; 2007; 21:265–273.

Double‐blinded Crossover Study with Marine Oil Supplementation Containing High‐dose icosapentaenoic Acid for the Treatment of Canine Pruritic Skin Disease

From this study it is evident that high-dose marine oil supplementation is an effective and apparently safe alternative to glucocorticoids for short-term relief of the symptoms of canine allergic skin disease.

Veterinary Dermatology; 1994; Vol. 5, Iss. 3, pp 99-104.

A blinded, placebo-controlled study of the efficacy of borage seed oil and fish oil in the management of canine atopy

This study has demonstrated that the high concentration of gamma-linolenic acid in borage seed oil, in combination with fish oil, does appear to possess an anti-inflammatory action.

Veterinary Record; 1999; 144, 405-407

Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic acid and fluoxetine, separately and in combination, in major depressive disorder

Fatty acids have also been found to influence the same pathways that anti-anxiety medications do, most notably fluoxetine, a commonly prescribed treatment for anxiety disorders in dogs.

Aust N Z J Psychiatry; 2008; 42(3): 192-198.


Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis

The meta-analysis suggests that probiotics can be used to prevent antibiotic associated diarrhoea and that S boulardii and lactobacilli have the potential to be used in this situation. 

Synbiotic Boost

10.1136/bmj.324.7350.1361 on 8 June 2002

Supplementation of diets with bovine colostrum influences immune function in dogs

Diets supplemented with Bovine Colostrum significantly influence immune response in dogs.

British Journal of Nutrition (2013), 110, 2216–2221

Probiotics‭: ‬Healthy From The Inside Out

The beneficial (“good”) bacteria contribute directly to the maintenance or restoration of health through multiple mechanisms, including the stimulation of the immune system, the processing of nutrients, and the production of vitamins and fatty acids that support normal intestinal function.

Nancy Loes, DVM MBA

Understanding the canine intestinal microbiota and its modification by pro-, pre- and synbiotics – what is the evidence?

This review summarises the current knowledge of the intestinal microbiome composition in the dog and evaluates the evidence for probiotic use in canine GI diseases to date.

DOI: 10.1002/vms3.17 (2016)

Efficacy Of Saccharomyces Boulardii As A Probiotic In Dogs With Lincomycin Induced Diarrhoea

S. boulardii was effective in treating lincomycin induced diarrhoea and to prevent the occurrence of diarrhoea when given together with lincomycin.

Bull Vet Inst Pulawy 51, 365-369, 2007

Effects of probiotic Lactobacillus acidophilus strain DSM13241 in healthy adult dogs

Probiotic was able to survive passage through the canine intestinal tract, leading to enrichment of the colonic microflora and local and systemic effects. 

AJVR, Vol 65, No. 3, March 2004

Oral Administration of β-1,3/1,6-Glucan to Dogs Temporally Changes Total and Antigen-Specific IgA and IgM

This study is the first to evaluate the adjuvant effect of orally administered β-1,3/1,6-glucans in healthy dogs on the total IgM, IgA, and IgG concentrations in serum; the IgA concentrations in tears and saliva; and the isotype-specific antibody response against Bordetella. There seems to be a temporary decrease in the switch from IgM toward IgA due to oral MacroGard supplementation in dogs, so that serum and mucosal IgA levels decrease. The same effect on a systemically induced serum antibody response against a Bordetella vaccine was seen.

Clinical and Vaccine Immunology, Feb. 2010, p. 281–285

Oat beta-glucan as a dietary supplement for dogs

It is concluded that oat beta-glucan extract can be used as a dietary supplement for dogs at a dose of 10 g/kg of food, being effective in reducing blood concentrations of total cholesterol, LDL-c and VLDL-c as well as CTTAD of nutrients. These results demonstrate the potential of using this type of beta-glucan in the diet of obese animals. In addition, by reducing the predominance of a Th2 response, oat beta-glucan can positively modulate the vaccine response of animals.

Vitamin C Protects Chondrocytes against Monosodium Iodoacetate-Induced Osteoarthritis by Multiple Pathways

Vitamin C possessed multiple capacities for prevention of OA progress.

Joint Guard

Mol. Sci. 2017, 18, 38; doi:10.3390/ijms18010038

Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Humans

VetPerine enhances the oral bioavailability of curcumin in both animals and humans.

Planta Med. 1998; 64(4):353-6

Therapeutic Roles of Curcumin: Lessons learned from Clinical Trials

Curcumin has shown therapeutic potential against a number of diseases, including Arthritis

The AAPS Journal, Vol. 15, No. 1, January 2013 (# 2012)

Rosehip - An Evidence based herbal medicine

Treatment with standardised rosehip powder consistently reduced pain scores.

Australian Family Physician Vol. 41, No. 7, july 2012

Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients?

Treatment with standardised rosehip powder consistently reduced pain scores.

Osteoarthritis and Cartilage (2008) 16, 965e972

Curcumin-attenuated trinitrobenzene sulphonic acid induces chronic colitis by inhibiting expression of cyclooxygenase-2.

Curcumin has therapeutic effects on TNBS acid-induced colitis, the mechanisms seem to be related to COX-2 inhibition and PGE2 improvement.

World J Gastroenterol 2006 June 28; 12(24): 3848-3853

Anti-Inflammatory Effects of Resveratrol, Curcumin and Simvastatin in Acute Small Intestinal Inflammation

Curcuminoids ameliorated acute inflammation of theP ileum by; increasing the level of anti-inflammatory cytokine IL-10, downregulating Th1-type immune responses

PLoS One 2010;5:e15099

Dietary Methyl Donor Depletion Protects Against Intestinal Tumorigenesis in ApcMin/+ Mice

Curcuminoids reduced expression inflammatory mediators such as CCL2, 1L-1β, 1L-6, and TNF-α, in the intestinal tissue of a mouse tumour model 

J Interferon Cytokine Res 2011;31:219-26

Effects of Edible Treats Containing Ascophyllum nodosum on the Oral Health of Dogs: A Double-Blind, Randomized, Placebo-Controlled Single-Center Study

A 90-day supplementation of dogs with kibbles containing A. nodosum seaweed resulted in significant improvements in several dental health indices and was beneficial for the prevention of plaque and calculus formation after a prophylactic dental procedure.

Kelp Seaweed

Front. Vet. Sci., 27 July 2018 

Effects of an Ascophyllum nodosum formulation on oral health index in dogs and cats.

A 6-week observation showed significant improvement of the oral health in dogs and cats of taking an A. nodosum product, in which, it was found administration of A. nodosum in dogs and cats reduced the rate of oral health index deterioration, as measured quantitatively with dental plaque and tartar.

Weterynaria W Praktyce (Veterinary in Practice) 10.

Synopsis of biological data on knobbed wrack Ascophyllum nodosum 

A. nodosum contains polysaccharides (e.g. ascophyllan, fucoidan & laminarin), amino acids, proteins, phenols, and an unique combination of vitamins and trace elements/minerals including vitamins B1, B2, B3, B12, C, E, K, biotin, carotene, folic acid, calcium, copper, iodine, iron, magnesium, zinc, etc

Baardseth E (1970)/ Food and Agriculture Organization of the United Nations

Laminarin from Irish Brown Seaweeds Ascophyllum nodosum and Laminaria hyperborea: Ultrasound Assisted Extraction, Characterization and Bioactivity

Ascophyllum nodosum and its natural compounds such as phenols and polysaccharides (e.g. ascophyllan, fucoidan & laminarin) have been found with antibacterial properties

Mar. Drugs 2015, 13, 4270-4280

Ascophyllan purified from Ascophyllum nodosum induces Th1 and Tc1 immune responses by promoting dendritic cell maturation.

Ascophyllum nodosum have been found with anti-inflammatory properties

Mar. Drugs 2014, 12, 4148-4164

Effects of ID-alG™ on weight management and body fat mass in high-fat-fed rats

Research was conducted using ID-aIG, when rats were fed ID-aIG (400mg/kg) for almost 9 weeks, in conjunction to a fat diet (high intensity), results showed that weight loss had occurred amongst the rats

Phytother Res. 2012 May;26(5):727-33.

Effects of seaweed supplementation on blood glucose concentration, lipid profile, and antioxidant enzyme activities in patients with type 2 diabetes mellitus

People with high sugar levels may also benefit from kelp. In a study conducted on 23 subjects, brown seaweed kelp ascophyllum nodosum (500mg) was given to the participants 30 minutes before the consumption of carbohydrate product, such as bread. It was noted that there was a decrease of 12.1 percent of insulin, while an increase of 7.9 percent in cederholm index was also recorded.

Nutrition Research and Practice (2008), 2(2), 62-67

Acute Post-Prandial Cognitive Effects of Brown Seaweed Extract in Humans

After a large carbohydrate-heavy lunch, half of the volunteers were given the supplement and the other half were given a placebo. Compared with their results on a pre-lunch cognitive test, the group receiving the supplement performed better at the cognitive tasks than the placebo group.

These findings are likely explained by the fact that components in brown seaweeds inhibit the key enzymes involved in the breakdown and absorption of carbohydrates, allowing for the steady blood sugar levels that allow the brain to function consistently well. Researchers call for future research to examine the effects on cognition in parallel with blood glucose and insulin responses.

Nutrients 2018, 10(1), 85

Silver-Zeolite Combined to Polyphenol-Rich Extracts of Ascophyllum nodosum: Potential Active Role in Prevention of Periodontal Diseases

The purpose of this study was to evaluate various biological effects of silver-zeolite and a polyphenol-rich extract of A. nodosum (ASCOP) to prevent and/or treat biofilm-related oral diseases

PLOS ONE; October 2014, Vol 9, Issue 10

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